Endocrine Abstracts

Background: Matrix metalloproteinases (MMPs) remodel extracellular matrix (ECM) in physiology as well as in cancer, inflammatory states and cardiovascular disease. In type 2 diabetes, there is evidence of activation of MMPs in vasculature, while decreased activity of MMPs and excessive accumulation of ECM is thought to contribute to the development of diabetic nephropathy.Material and methods: We measured serum MMP-2, MMP-9 in 22 subjects with type 2 DM ...